Rimonabant Advantages/Benefits
In short Rimonabant (Zimulti) benefits for :
1) Weight Loss
2) Cardiovascular Risk
3) Smoking Cessation
Weight Loss
Rimonabant-Acomplia (discovered and developed by Sanofi-Aventis) is a CB1 endocannabinoid receptor antagonist. CB1 blockers act on the endocannabinoid system, a system controlling energy and nicotine dependence, reducing the overstimulation thought to lead to obesity and nicotine addiction. In a recent study, 1,036 overweight or obese patients with blood lipid disorders were randomly placed in one of three groups (placebo vs. 5 mg or 20 mg per day of Rimonabant-Acomplia). After one year of treatment, patients receiving 20 mg per day of Rimonabant-Acomplia lost an average of 20 pounds.
Cardiovascular Risk
Sanofi-aventis’ drug rimonabant (Acomplia) may aid in controlling blood sugar levels in type-2 diabetes, offering a new avenue in diabetes management.
Results from the year-long RIO-Diabetes trial, published in The Lancet, found that rimonabant 20 mg once daily significantly improved several cardiometabolic risk factors in patients whose diabetes was uncontrolled by metformin or sulfonylurea. Improvements were recorded in weight, HbA1c, HDL- cholesterol, triglycerides, systolic blood pressure and waist circumference. 50% of the improvements in HbA1c and HDL-cholesterol levels were independent of the weight loss achieved, indicating a direct effect of rimonabant on these parameter.
Smoking Cessation
The drug has potential as a treatment for smoking cessation because the endocannabinoid system is involved in the body's response to tobacco dependence. While studies are ongoing, initial results are favorable toward rimonabant, with subjects taking rimonabant being able to quit at a statistically higher rate than subjects taking a placebo. Nonetheless, the FDA has suggested that on the current studies it does not currently intend to approve rimonabant for this use.
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